There are many diabetic problems and there are two different groups of scientists trying to find the answers. Unfortunately, there is little co-operation taking place and yet the research being done in one area is amazing. This paper will discuss resveratrol, a polyphenol found in red wine. Resveratrol has been explored in formal studies in almost every country on earth. Much of this research has been in areas of anti-aging and yet it explored many of the common problems diabetics have to deal with in their daily lives. Essentially, science has concentrated their research in specific diabetic areas such as: diabetic mellitus, which is the most common cause of metabolic neuropathy, diabetic neuropathy, and general diabetes.
The strongest point that has attracted so much attention to resveratrol is its ability to overcome problems caused by a diabetic condition. Diabetics are constantly trying to control their blood sugar and glucose. In the research of the past few years, it has been found that a diabetic can now more successfully gain better control over his glucose and blood sugar level. Diabetics have also found they can reduce their inflammation. All of these advances are acting to extend an individual’s life span.
Let me explain resveratrol and its history so you can understand why it has become so important. First, resveratrol is a natural compound produced by plants and food groups, especially grape vines. It extends lifespan and health span by increasing the performance of mitochondria, a cell’s energy source.
A professor of genetics at Harvard Medical school, David Sinclair, discovered resveratrol and wrote an article published in the Journal, Cell Metabolism. Sinclair has published a number of studies which describe how resveratrol improves energy production and improves health in cells by energizing a class of genes called sirtuins which are an integral part of mitochondrial function. This was a very important accomplishment as this is a key source of power for the mitochondria and is essential for increasing lifespan and good general health.
Sinclair and his team of scientists studied the sirloin genes in many different organisms, such as worms, flies, yeast and mice. Sinclair and his team were successful in knocking out the SIRT1 demonstrating that cells lacking the SIRT1 gene would not respond to resveratrol. This was important because no one had been able to demonstrate what caused a change in the mice. But if the mice did not have the SIRT1 gene, they would die at birth.
Sinclair had two of his students solve this problem by engineering a new mouse model. The mice seemed to be normal, yet they were designed so that the SIRT1 gene would switch off if the mice were given the drug Tamoxifen. Sinclair decribed Tamoxifen as an inductible drug causing the whole body to delete the SIRT1 gene.
Sinclair explained the results of the Tamoxifen as being obvious. When the mice were given small doses of resveratrol after the SIRT1 was disabled Sinclair could not find any discernible improvement in mitochondrial function. Whereas the mice with normal SIRT1 function demonstrated dramatic increases in energy.
In the June, 2006 issue of the “American Journal of Physiology, Endocrinology and Metabolism,” a study was reported. The journal reported on a ten-week study conducted in Taiwan. Hui-Chen Su and colleagues reported on their research which involved the following: diabetic rats that were either 8-weeks old or 10-weeks old. These rats were treated with resveratrol. On the 14th day of treatment, the rats’ glucose had fallen by 25.3 percent; triglycerides reduced by 50.2 percent. Resveratrol raised the amount of glucose taken in by the skeletal muscles, while fat cells and liver cells were stimulated to store glucose. The rats also lost their desire to eat and drink a lot, both being symptoms of diabetes mellitus.
After the study was completed, the researchers concluded; “The exact mechanism underlying the insulin-like activity of resveratrol requires more research.”
DISCLAIMER: I am not a Doctor and do not give medical advice; this is a news report and cannot substitute for the advice of a medical professional
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