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The Brain Mediates Resveratrol’s Anti-diabetic Actions

Resveratrol, a bioflavonoid, improves diabetes in diabetic rodents when they ingest it orally. This has been substantiated by various research studies. But there was very little known how these beneficial changes are mediated in rodent’s body. Now there is evidence from a new study that answers that question. Endocrinology, journal of The Endocrinology Society, reports the brain has a key role in mediating resveratrol’s anti-diabetic actions. This finding is potentially pointing the direction for future orally-delivered diabetes medications which target the brain. Read the rest of this entry »

The Brain, Resveratrol and Diabetes

University of Texas Southwestern Medical Center conducted a research study that found resveratrol lowered blood sugar and improved insulin levels when the resveratrol was injected directly into the brains of mice fed a very high calorie diet. This finding indicates the brain plays a key role in resveratrol’s positive effect on diabetes. It also indicates the benefits could occur independently of diet and body weight.

The research study’s data gives strong evidence that the brain has a principle role in resveratrol’s positive effect on diabetes and that this positive influence could happen independently of diet or weight. If this data is correct it could lead to a brand new type 2 diabetes treatment that would target the brain. Unfortunately, red wine is not likely to improve blood sugar and insulin levels because resveratrol does not cross the blood-brain barrier very easily. Dr. Coppari, member of the research team, stated that drinking red wine is not likely to improve blood sugar. It would not be practical for anyone to drink enough red wine to get the brain to accumulate the amount of resveratrol delivered in the study. It would take many bottles of wine and that would be very unhealthy. Read the rest of this entry »

Resveratrol Diabetes Treatment Targets the Brain

The journal, Endocrinology, a publication of The Endocrine Society, will be publishing an article on a study that investigated how the brain has an important role in mediating resveratrol’s anti-diabetic actions, and possibly lays the foundation for future orally-delivered diabetes medications which target the brain.

Sirtuins stimulated by resveratrol are a class of proteins considered to support a majority of resveratrol’s positive effects of calorie restrictions. Sirtuins will be found in all parts of the human body, only now is science beginning to understand the importance of sirtuins. Dr. Roberto Coppari, PhD, of the University of Texas Southwestern Medical Center is the co-author of the study. Dr. Coppari wants to learn what tissues mediate resveratrol’s positive effects on the body. He commented, “We know that sirtuins are expressed in parts of the brain known to govern glucose metabolism, so we hypothesized that the brain could be mediating resveratrol’s anti-diabetic actions.” The hypothesis was tested by assessing the metabolic consequences of delivering resveratrol directly into the brain of diabetic mice which resulted in improving their high levels of blood sugar and insulin. Read the rest of this entry »

DISCLAIMER: I am not a Doctor and do not give medical advice; this is a news report and cannot substitute for the advice of a medical professional.