The journal, Endocrinology, a publication of The Endocrine Society, will be publishing an article on a study that investigated how the brain has an important role in mediating resveratrol’s anti-diabetic actions, and possibly lays the foundation for future orally-delivered diabetes medications which target the brain.

Sirtuins stimulated by resveratrol are a class of proteins considered to support a majority of resveratrol’s positive effects of calorie restrictions. Sirtuins will be found in all parts of the human body, only now is science beginning to understand the importance of sirtuins. Dr. Roberto Coppari, PhD, of the University of Texas Southwestern Medical Center is the co-author of the study. Dr. Coppari wants to learn what tissues mediate resveratrol’s positive effects on the body. He commented, “We know that sirtuins are expressed in parts of the brain known to govern glucose metabolism, so we hypothesized that the brain could be mediating resveratrol’s anti-diabetic actions.” The hypothesis was tested by assessing the metabolic consequences of delivering resveratrol directly into the brain of diabetic mice which resulted in improving their high levels of blood sugar and insulin. Read the rest of this entry »