In 1997, Dr. Sinclair discovered new strains of yeast that had a very long life span. His discovery of extended longevity happened because a gene called sir2 had experienced starvation, and the gene mediated the extension of life. This was a major step forward to validate caloric restriction. This caused resveratrol to be considered the most effective stimulator of sirtuin enzymes, Scientists adopted the notion that the anti-aging enzymes, sirtuin enzymes are the universal regulators of aging in virtually all living organisms. Dr. Sinclair’s group successfully demonstrated, at that time, they could tweak the sirtuin pathway.  They accomplished this by screening a number of biologically active compounds and found several compounds they tested could be easily made into a drug. Read the rest of this entry »